| ORIGINAL ARTICLE | |
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Synthesis of New Amino-1,5-Benzodiazepine and Benzotriazole Derivatives from Dimedone Norah Bennamane, Rachedine Kaoua, Lamouri Hammal and Bellara Nedjar-Kolli, Org. Commun. (2008), 1:3; 39-47 Laboratory of Applied Organic Chemistry, University of Sciences and Technology, Houari Boumediene, BP 32, El-Alia, Algiers, Algeria Abstract: High-yielding syntheses of two unpublished series of amino-1,5-benzodiazepines derivatives 3 and 1,2,3-benzotriazoles 4 bearing a dimedone moiety are respectively reported. Derivatives 3 were obtained by intramolecular cyclisation using cyanogenbromide of enaminone 2. On the other hand, when enaminones 2 were treated with sodium nitrite under acidic conditions, cyclisation led to benzotriazole 4.
Keywords: Dimedone; benzotriazoles; benzodiazepines, cyanobromide; enaminones. |