Ring expansions using Baeyer-Villager oxidation: An efficient strategy for the construction of substituted AB-ring systems
Bello Y. Makama
Org. Commun. (2010), 3:4 ; 84-91
Department of Petroleum Chemistry, American University of Nigeria, Lamido Zubairu Way, P.M.B. 2250 Yola, Adamawa State, Nigeria
Abstract: An approach to the synthesis of regioselective cis fused substituted AB-ring systems is described. The key step involves a thermal cycloaddition to substituted cyclobutanones. The resulting cyclobutanones were subjected to regioselective Baeyer-Villager oxidation protocol.
Keywords: Bicyclic lactones; thermal; cyclcoaddition; cyclobutanone; Baeyer-Villager oxidation . |