Synthesis and biological studies of novel 2-(4-substitutedbenzyl-thio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4- chlorophenyl)pyrido--[2,3-d]-pyrimidin-4(3H)-one derivatives
M. Suresh, P. Lavanya, K. Naga Raju, Sreekanth B. Jonnalagaddaand C. Venkata Rao
Org. Commun. (2011), 4:2 ; 33-41
School of Chemistry, University of KwaZulu-Natal, Westville Campus, P Bag X 54001, Durban 4000, SOUTH AFRICA.
Department of Chemistry, Sri Venkateswara University College of Sciences, Sri Venkateswara University, Tirupati-517 502, INDIA
Abstract: A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, 1H-NMR, 13C NMR, LCMS mass spectra and elemental analysis.
Keywords: 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]-pyrimidin-4(3H)-one; antibacterial; antifungal. |