A Simple and efficient protocol for the synthesis of quinoxalines catalyzed by pyridine
Sachin B. Wadavrao, Ramesh S. Ghogare and A. Venkat Narsaiah
Organic & Biomolecular Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India
Abstract: A simple and efficient protocol has been developed for the synthesis of quinoxalines. In the synthesis, the reaction of 1,2-phenylenediamines and phenacyl bromide were carried out using pyridine as a catalyst in THF at room temperature to give quinoxalines. This method is applicable to a variety of substrates to afford the corresponding derivatives in excellent yields.
Keywords: Phenacyl bromide;1,2-phenylenediamines; pyridine; quinoxalines. |