Facile synthesis, characterization and antimicrobial activities of diphenylphosphoryl derivatives of substituted aryl and nitrogen heterocycles
G. Subba Reddy, K. Uma Maheswara Rao, S. Santhi Sudha, N. Bakthavatchala Reddy, Ch. Syama Sundar, C. Naga Raju and C. Suresh Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
Abstract: Diphenylphosphoryl derivatives of substituted aryl and nitrogen heterocycles were prepared by a one-pot process involving sequential reaction of diphenylphosphine chloride with dry methyl alcohol/ethyl alcohol and then with different halides of substituted nitrogen heterocycles/aryl halides. The title compounds (5a-j) structures were established by analytical, IR, NMR ( 1H, 13C and 31P) and mass spectra, and they have been screened for their antimicrobial activity. They exhibited significant antibacterial and antifungal activity.
Keywords: Diphenylphosphoryl derivatives; Nitrogen heterocycles; antibacterial activity; antifungal activity. |