Synthesis and antioxidant activity of dioxazaphosphinin-2-ones
N. Bakthavatchala Reddy, Ch. Syama Sundar, S. H. Jayaprakash, G. Mohan, P. Vasugovardan Reddy and C. Suresh Reddy
Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
Department of Chemistry, Yogi Vemana University, Kadapa - 516 003, India
Abstract: A simple and efficient synthesis of dioxazaphosphinin-2-ones has been developed by the cyclisation of 2-hydroxy-1,2-diphenylethanoneoxime with phosphorus oxychloride in the presence of triethylamine in dry THF to afford the corresponding monochloride. In the next step, subsequent reaction of monochloridewith different amines at 50-60 ˚C for 2-3 hours resulted in the formation of the title compounds (4a-j). The lead compounds were screened for their antioxidant activity.
Keywords: 2-hydroxy 1,2-diphenylethanoneoxime ; POCl 3; dioxazaphosphinin-2-ones; Antioxidant activity. © 2014 ACG Publications. All rights reserved. |