Potassium carbonate mediated one-pot synthesis and antimicrobial activities of 2-alkoxy-4-(aryl)-5H-indeno[1,2-b]pyridine-3-carbonitriles

Şahin Öztürk, Meliha Burcu Gürdere, Hayreddin Gezegen, Mustafa Ceylan and Yakup Budak

Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, 60250, Tokat, Türkiye

Department of Nutrition and Dietetics, Faculty of Health Science, Cumhuriyet University, Sivas, Türkiye

Abstract. 2-Alkoxy-4-(aryl)-5H-indeno[1,2-b]pyridine-3-carbonitriles (3a-e and 4a-e) were synthesized via multicomponent reaction from 2-aryl-methylidineindan-1-ones (1a-e), malononitrile and K 2CO 3 in ethanol and/or methanol. The structures of obtained compounds (3a-e and 4a-e) were characterized using the spectroscopic methods (NMR, IR) and elemental analysis. Addition, the in vitro antimicrobial activities of compounds (3a-e) were tested against the five human pathogenic bacteria. Penicillin G and Ceftriaxone antibiotics were used as positive control. The results were given as MIC values (minimum inhibition concentration), and compounds 3b-d showed very high activity against Escherichia coli 111.

Keywords: 1-Indanone; malononitrile; pyridine-3-carbonitrile; antimicrobial activity. © 2016 ACG Publications. All rights reserved.