Synthesis, characterization, in vitro antiproliferative and cytotoxicity effects of a new class of 2-((1R,2S)-2-((E)-4-substitutedstyryl) cyclooctyl)benzo[d]thiazole derivatives
Muhammad Mehdi Uremis , Ayşe Şahin Yağlıoğlu , Yakup Budak and Mustafa Ceylan
Department of Medical Biochemistry, Medical Faculty, Kahramanmaras Sutcu Imam University, 46040, Kahramanmaras, Türkiye
Department of Chemistry, Faculty of Science, Çankırı Karatekin University, 18100 Çankırı,Türkiye
Department of Chemistry, Faculty of Art and Science, Gaziosmanpasa Univesity, 60250, Tokat, Türkiye
Abstract:The novel 2-((1R,2S)-2-((E)-4-substitutedstyryl) cyclooctyl)benzo[d]thiazole s(12-14)were synthesized from the reaction of 10-(4-substitutedbenzylidene)bicyclo[6.2.0]decan-9-ones (5a-8a) with 2 -aminothiophenol (11) in the presence ofp -TsOH at reflux conditions in good yields. The antiproliferative activities of 12-14 were determined againts C6 (rat brain carcinoma) and HeLa (human cervical carcinoma) cell lines using BrdU cell proliferation ELISA assay. 5-Fu (5-fluorouracil) was used as standard. The antiproliferative activities of 12-14 and the control were investigated on eight concentrations (5, 10, 20, 30, 40, 50, 75 and 100 µM). The results showed that the synthesized compounds had significant antiproliferative activity and low cytotoxicity effects.
Keywords : Benzothiazole ; anticancer; cytotoxicity; HeLa; C6. © 2017 ACG Publications. All rights reserved.