5.

Antiproliferative Effects of the Methanolic Extracts of Sideritis libanotica Labill. subsp. linearis

Ibrahim Demirtas, Ayse Sahin, Bulent Ayhan, Saban Tekin and Isa Telci

Laboratory of Plant Research, Department of Chemistry, Faculty of Science and Art, Gaziosmanpaşa University, Taşlıçiftlik Campus, 60240 Tokat, Türkiye

Laboratory of Molecular Biology, Department of Biology, Faculty of Science and Art, Gaziosmanpaşa University, Taşlıçiftlik Campus, 60240 Tokat, Türkiye

Department of Field Crops, Agricultural Faculty of Gaziosmanpasa University , Tokat, Türkiye

Abstract: Methanol extract from aerial parts of Sideritis libanotica Labill. subsp. linearis (Bentham) Borm. were investigated for its in vitro antiproliferative activities against Vero, HeLa and C6 cells. The tests were carried out as dose-dependent assay starting from 25 µg/mL to 250 µg/mL. The extract found to be active against African green monkey kidney (Vero), human uterus carcinoma (HeLa) and Rat Brain tumor cells (C6) cancer cell lines with IC 50 values. The methanol extract of S. libanotica showed the highest activity against the Vero, HeLa and C6 cell lines at 250 µg/mL as dose-dependent assay starting from 25 µg/mL.

Keywords: Antiproliferation; Sideritis libanotica; Vero cells; plant extracts.