7.

Bioactive Chemical Constituents of a Sterile Endophytic Fungus from Meliotus dentatus

Hidayat Hussain, Karsten Krohn, Siegfried Draeger, Kathrin Meier and Barbara Schulz

Department of Chemistry, Universität Paderborn, Warburger Straße 100, 33098 Paderborn, Germany

Institut für Mikrobiologie, Technische Universität Braunschweig, Spielmannstraße 7, 31806 Braunschweig, Germany

Abstract: Chemical and biological investigations of the endophytic fungus of an unidentified Ascomycete, isolated from Meliotus dentatus led to the isolation of six known polyketide metabolites (1–6) and two steroids (7 and 8). Compounds 1–3, and 5 were tested for antibacterial, antialgal and antifungal activities. Compounds 2 , 3, and 5 showed good activity against the alga Chlorella fusca, while compounds 2 and 3 were active against the Gram negative bacterium Escherichia coli and compounds 3 and 5 also against the Gram positive Bacillus megaterium. Similarly, c ompounds 3 and 5 also showed antifungal activity against Microbotryum violaceum

Keywords: Endophytic fungus; Meliotus dentatus ; polyketides; steroids; biological activity.