10.

Flavonoid Constituents from Algerian Launaea resedifolia (O.K.),and their Antimicrobial Activity

Fairouz Moussaoui, Amar  Zellagui,  Narimane Segueni,  Ahmed Touil and Salah Rhouati

Laboratory of natural products and organic synthesis, Department of  Chemistry, Faculty of Science, University Mentouri – Constantine Algeria.

Abstract: A chemical investigation of the aerial parts of Launea resedifolia (O.K.) afforded four flavonoids, apigenin 1, luteolin 2, apigenin 7-O-β-glucoside 3 and apigenin 7-O-β-glucuronide 4. The structures of the isolated compounds were established by chromatographic behaviour and by means of UV, NMR and MS spectral analysis. Moreover, the antimicrobial activity of two isolated flavonoids 3, 4 and the n-BuOH extract against eleven bacteria and one fungus was studied. It was found that the most powerful effect was against Morganella morgani; Streptococcus Sp; Enterobacter Sp. and Proteus mirabilis.

Keywords: Launaea resedifolia O.K;, Asteraceae; flavonoids; antimicrobial activity.