A new Labdane Diterpene and Other Constituents from Marrubium deserti Noe ex coss.
Hocine Dendougui, Souad Seghir, Zahia Belloum, Fadila Benayache, Francisco Leon, Ignacio Brouard, Jaime Bermejo and Samir Benayache
Laboratory of Valorization of Natural Resources, University Mentouri of Constantine, Algeria.
Laboratory of Phytochemistry and Physico-Chemical and Biological Analysis, University Mentouri of Constantine, Algeria.
Instituto Productos Naturales y Agrobiología- Instituto Universitario de Bioorgánica A. G ., Tenerife, Spain
Abstract: The phytochemical study of the chloroform soluble part of the hydroalcoholic extract of Marrubium deserti allowed us to describe a new labdane diterpene, 6-dehydroxy-19-acetyl-marrubenol (3) beside three other diterpenes : 19-acetyl-marrubenol (6) , 6-acetyl-marrubenol (7) and 16-epoxy-9-hydroxy-labda-13(16), 14- diene (1). This latter derivative is described for the first time as natural compound. Phytol (2), and three sterols: b -sitosterol (4), stigmasterol (5) and b -sitosterol 3-O-glucoside (8) were also isolated from this species. Structure elucidation of the isolated compounds was accomplished by means of spectroscopic techniques, especially NMR spectroscopy and mass spectrometry.
Keywords:Lamiaceae; Marrubium deserti; diterpenoids, Sterols; phytol. |