4.

Cycloartane Glycosides from Astragalus erinaceus

Tahir Savran, Derya Gülcemal, Milena Masullo, Tamer Karayıldırım, Emre Polat, Sonia Piacente and Özgen Alankuş-Çalışkan

Ege University, Faculty of Science, Department of Chemistry, Bornova, 35100, İzmir, Türkiye

Università degli Studi di Salerno, Dipartimento di Scienze Farmaceutiche e Biomediche, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy

Abstract: One new cycloartane-type saponin, 3-O-[ β -D-xylopyranosyl-(1 → 2)- β -D-xylopyranosyl]-6-O- β -D-glucuronopyranosyl-3 β ,6 α ,16 β ,24(S),25- pentahydroxyxyxloartane (1) was isolated from the MeOH extract of whole plant parts of Astragalus erinaceus along with 5 known saponins (2-6), cyclodissectoside, cycloastragenol, 6-O- β -D-glucopyranosyl-3 β ,6 α ,16 β ,24(S),25-pentahydroxycycloartane, oleifolioside B and 3,6-di-O- β -D-xylopyranosyl-3 β ,6 α ,16 β ,24(S),25-pentahydroxycycloartane, respectively. Their structures were established by the extensive use of 1D- and 2D-NMR experiments along with ESIMS and HRMS analysis. The glucuronic acid moiety in cycloartanes is a very unusual finding.

Keywords: Astragaluserinaceus; Leguminosae; cycloartane; glucuronic acid; saponin.