7.

Chemical Constituents of the Sponge Mycale Sp ecies from South China Sea

Xuefeng Zhou, Xiuping Lin, Xieyang Guo, Bin Yang, Xian-Wen Yang and Yonghong Liu

Key Laboratory of Marine Bio-resources Sustainable Utilization / Guangdong Key Laboratory of Marine Materia Medica / Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

Abstract: Chemical investigation of the sponge Mycale species from the South China Sea afforded eleven known compounds, henicosanoic acid methyl ester (1) , hexadecyl ethers of glycerol ( 2 ) , N-docosanoyl-D-erythro-(2S,3R)-16-methyl-heptadecasphing-4(E)-enine ( 3 ) , dibutyl phthalate ( 4 ) , cholesterol ( 5 ) , 5α,8α-epidioxycholest-6,22-dien-3β-ol ( 6 ) , 5-hexadecyl-pyrrole-2-carboxaldehyde ( 7 ) , benzoic acid ( 8 ) , 4-hydroxybenzoic acid ( 9 ) , thymine ( 10 ) ,and uracil ( 11 ) . Compounds 1 – 4 , 6 – 9 were obtained from the sponge of the genus Mycale for the first time, and 4 and 6 showed toxicity in the brine shrimp lethality test with the LD 50 values at 2.9 μg/mL and 4. 7 μg/mL, respectively .

Keywords: S ponge Mycale species ; C hemical c onstituents ; Brine shrimp lethality test.