Radical Scavenging and DNA Cleavage Inhibitory Activities of 2,3-Dihydroxybenzoyl Glycine Obtained from Bacillus subtilis
Jayesh J. Ahire, Pramod P. Mahulikar and Bhushan L. Chaudhari
Department of Microbiology, School of Life Sciences,
School of Chemical Sciences, North Maharashtra University, .Box. 80, Jalgaon 425001, Maharashtra, India
Abstract: A catecholate type of iron chelator (siderophore); 2,3-dihydroxybenzoyl glycine (DHBG) was produced by Bacillus sp. under i ron stress conditions. Pure DHBG was subjected for DPPH ( α,α−Diphenyl−β− Picrylhydrazyl ) radical scavenging activity and radical induced DNA cleavage inhibition assay. In results, DHBG showed the highest radical scavenging effect and DNA cleavage inhibition activity when it was free from iron. This study revealed antioxidative potential of iron chelator DHBG; and its probable mechanism.
Keywords: Catechol; 2,3-dihydroxybenzoyl glycine; Bacillus sp.; DPPH radical; Iron |