A New Compound Along With Seven Known Compounds from an Endophytic Fungus Aspergillus sp. HS-05
Gang Chen, Lin Zhang, Haifeng Wang, Hong-Hua Wu, Xuan Lu, Yue-Hu Pei, Xin Wu, Bo Pan, Hui-Ming Hua and Jiao Bai
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China;
Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University), Ministry of Education , Shenyang 110016, China;
School of Life Sciences and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China
Abstract: Investigation of EtOAc extract from the fermentation broth of the endophytic fungus Asperilligus sp. HS-05 led to the isolation of a new compound (1) of spiro moiety named aspergispiroketal and seven known compounds (2-8). Their structures were elucidated mainly by NMR and HR-TOF-MS, as well as on comparison with the reported data. The absolute configuration of 1 was defined by comparison of quantum chemical TDDFT calculated and experimental ECD spectra.
Keywords: Asperilligus sp.; endophytic fungus; ECD |