24.

Chemical Constituents and their DPPH Radical Scavenging Activity of Nepalese Crude Drug Begonia picta

Khem Raj Joshi, Hari Prasad Devkota, Takanori Nakamura, Takashi Watanabe and Shoji Yahara

Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo ku, Kumamoto, 862-0973, Japan

Program for Leading Graduate School “HIGO (Health life science: Interdisciplinary and Glocal Oriented) Program”, Kumamoto University, Kumamoto, 862-0973, Japan

Department of Pharmaceutical Health Care, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, Hyougo, 670-8524, Japan

Research Organization for Regional Alliances, Kochi University of Technology, 185 Miyanokuchi, Tosayamada, Kami City, Kochi 782-0003, Japan

Abstract: Vitexin (1), isovitexin (2), orientin (3), isoorientin (4) and 1, 3 - dih y d roxy - 6, 7 - dimethoxyxanthone (5) were isolated from the whole plant of Begonia picta , a Nepalese crude drug commonly known as “ Magarkaanche ”. Structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from B. picta and their in vitro antioxidant activity was evaluated by diphenyl-2-picrylhydrazyl ( DPPH ) free radical scavenging assay. Compounds 3 and 4 showed significant free radical scavenging activity.

Keywords: Begoina picta; vitexin; orientin; Flavonoid; Xanthone. © 2015 ACG Publications. All rights reserved.