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Norditerpenoid alkaloids from Delphinium kohatense Munz

Farzana Shaheen, Manzoor Ahmad, Tania Shamim Rizvi and Liaqat Ali

HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

Department Chemistry, University of Malakand, Chakdara, Dir (L), Pakistan

Department of Biological Sciences and Chemistry, University of Nizwa, Birkat Al-Mauz, Nizwa-616, Oman

Abstract: A new aconitine-type norditerpenoid alkaloid, kohatenine (1) [10β-hydroxy-1α,8β,16β-trimethoxy-6α,14α-diacetyl-N-ethyl aconitane], along with four known alkaloids, condelphine (2), talatisamine (3), peregrine (4), and 14-O-acetyltalatisamine (5), was isolated from the aerial parts of Delphinium kohatense Munz. The structure of the new compound was deduced on the basis of combined MS (EI and FAB) and NMR (1D and 2D) spectroscopic techniques. The known compounds were confirmed by comparison of the physical and spectroscopic data with those reported in literature.

Keywords: Norditerpenoid alkaloids; Kohatenine; Delphinium kohatense; Ranunculaceae. © 2015 ACG Publications. All rights reserved.