Records of Natural Products

Year: 2016  Volume: 10  Issue: 1




Bioactive Secondary Metabolites from the Endophytic Aspergillus Genus

Huawei Zhang, Yifei Tang, Chuanfen Ruan and Xuelian Bai

School of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China

College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 310036, P. R. China

Abstract: A growing evidence indicates that the endophytic fungus Aspergillus is one of rich sources of natural products with a broad spectrum of biological activities. Up to now, 162 secondary metabolites had been structurally identified from 11 endophytic Aspergillus spp. and 67 of them were shown to have strong bioactivities with potential application in drug discovery. This review focuses on biology and chemistry of endophytic Aspergilli, especially their bioactive secondary metabolites. Covering: 2004 to 2014.

Keywords: Aspergillus genus; secondary metabolites; chemical constituent; bioactivity, progress. © 2015 ACG Publications. All rights reserved.