Antiplasmodial Activity and Cytotoxicity of Isolated Compound from the Stem bark of Anthocleistaliebrechtsiana

Theodora K. Kowa, Denis Zofou, Roukayatou Mbouangouere, Michel F. Tala, Hippolyte K. Wabo, Ning-Hua Tan, Vincent P.K. Titanji and Pierre Tane

Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon

Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O. Box 6163, Yaounde, Cameroon

Biotechnology Unit, University of Buea, P.O. Box 63, Buea, Cameroon

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, P.R. China

Abstract: One new cerebroside derivative, namely liebrechtsianoside A (1), along with five known compounds: tetracosanoic acid (2), swertiaperennin (3), decussatin (4), swertianin (5) and β-sitosterol glucoside (6) were isolated from the the stem bark of Anthocleista liebrechtsiana . Their structures were elucidated by interpretation of NMR and MS data, and by comparison of these data with those reported in literature. Compound 1 showed the highest antiplasmodial activity against Dd2 chloroquine-resistant strain of Plasmodium falciparum.

Keywords:Anthocleista liebrechtsiana; Loganiaceae; cerebroside; Structure elucidation; Antiplasmodial activity . © 2015 ACG Publications. All rights reserved.