11.

Two New Dammarane Triterpenes from the Leaves of Ceriops tagal

Xin Wu, Hongbo Liao, Xiaohui Zhu, Hongyu Lu, Xiaobin Zeng, Liao Cui, Xiaohua Lv, Yanqun Li and Chaohua Zhang

Guangdong Key Laboratory for Research and Development of Natural Drugs,

Department of Pharmacology,

Department of Pathology & Pathophysiology, Guangdong Medical University, Zhanjiang, Guangdong 524023, P. R. China

Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety,

Key Laboratory of Advanced Processing of Aquatic Products of Guangdong Higher Education Institution, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong 524088, P. R. China

Abstract: T wo new dammarane triterpenes , cereotagalol C ( 1 ) and cereotagalol D (2 ), were isolated from the leaves of Ceriops tagal. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D-, 2D-NMR and HR -ESI -MS. Their cytotoxic activities against A549, HepG2, HCT-116 and CNE-2 cell lines were also evaluated, which revealed that compounds 1 and 2 had selected moderate cytotoxicity against HCT-116 and CNE-2 with IC 50 values of 29.7 and 37.2 μ M, respectively.

Keywords: Dammarane triterpenes ; Ceriops tagal ; spectroscopic analyses; cereotagalol C; cereotagalol D . © 2016 ACG Publications. All rights reserved.