8.

(-)-8-Oxohobartine a New İndole Alkaloid from Aristotelia chilensis (Mol.) Stuntz

Cristian Paz, Jose Becerra, Mario Silva, Jaime Cabrera-Pardo Viviana Burgos, Matthias Heydenreich and Bernd Schmidt

Department of Chemistry, Universidad de La Frontera, Chile

Laboratory of Chemistry of Natural Products, University of Concepción, Chile

Institute of Chemistry, University of Potsdam, Germany

Abstract: The fruit of Aristotelia chilensis is considered a “super fruit” due to its high concentration of polyphenols displaying exceptional antioxidant capacities ORAC. From maqui berries have been reported several anthocyanins and glycosylated flavonoids, those benefits increase the attention to restudy the plant. From the leaves of A. chilensis several indole alkaloids have been reported, we in addition to aristoteline, aristone, aristoquinoline and 3-fromylindole report the spectroscopic elucidation of 8-oxo-9-dehydromakomakine (1), hobartine (2) and a new alkaloid named 8-oxohobartine (3). Compound 1 to 3 did not show bactericidal activity against E. coli and S. aureus till 200 μg.

Keywords: Aristotelia chilensis; indole alkaloids; 8-oxohobartine. © 2015 ACG Publications. All rights reserved.