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A New Sesquiterpenoid Derivative from the Coastal Saline Soil Fungus Aspergillus fumigatus

Desheng Liu, Yuling Huang, Chunmin Li, Liying Ma, Xiaohong Pan, Daneel Ferreira and Weizhong Liu

College of Pharmacy, Binzhou Medical University, Yantai, Shandong 264003, P. R. China

Jinan Maternity and Child Care Hospital , Jinan, Shandong, 250001, P. R. China

Department of Biomolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, Mississippi 38677-1848, United States

Abstract: A new sesquiterpenoid derivative, named aspergiketone (1), along with seven known compounds (2-8) were isolated from the coastal saline soil fungus Aspergillus fumigatus. Their structures were elucidated by spectroscopic analysis, and by comparison of experimental and reported data. The absolute configuration of compound 1 was defined by X-ray diffraction analysis. Compound 1 was cytotoxic towards HL-60 and A549 cell lines with IC 50 values of 12.4 and 22.1 μ M , respectively.

Keywords: secondary metabolites; Aspergillus fumigatus; cytotoxic activity; coastal saline soil. © 2016 ACG Publications. All rights reserved.