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Calotroposide S, New Oxypregnane Oligoglycoside from Calotropis procera Root Bark

Sabrin R. M. Ibrahim, Gamal A. Mohamed, Lamiaa A. Shaala and Diaa T. A. Youssef

Department of Pharmacognosy and Medicinal Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 41477, Saudi Arabia

Department of Pharmacognosy , Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt

Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

Department of Pharmacognosy , Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt

Natural Products Unit , King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

Suez Canal University Hospital, Suez Canal University, Ismailia 41522, Egypt

Abstract: Calotroposide S (1), a new oxypregnane oligoglycoside has been isolated from the n-butanol fraction of Calotropis procera (Ait) R. Br. root bark. The structure of 1 was assigned based on various spectroscopic analyses. Calotroposide S (1) possesses the 12-O-benzoylisolineolon aglycone moiety with eight sugar residues attached to C-3 of the aglycone. It showed potent anti-proliferative activity towards PC-3 prostate cancer, A549 non-small cell lung cancer (NSCLC), and U373 glioblastoma (GBM) cell lines with IC 50 0.18, 0.2, and 0.06 µM, respectively compared with cisplatin and carboplatin.

Keywords:Calotropis procera; Asclepiadaceae; calotroposide S; anti-proliferative activity . © 2016 ACG Publications. All rights reserved.