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New Secondary Metabolites from an Endophytic Fungus in Porodaedaleapini

Shuen -Shin Yang, Ming-Jen Cheng, Hing-Yuen Chan, Sung-Yuan Hsieh, Ho-Cheng Wu, Gwo - Fang Yuan, Chu-Hung Lin, Hsun-Shuo Chang and Ih -Sheng Chen

Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsi u ng 807, Taiwan

Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohs i ung 807, Taiwan

Research Center for Natural Products and Drug Development, Kaohsiung Medical University, Kaohs i ung 807, Taiwan.

Abstract: Eight benzenoids including three new phenols, piniphenols A–C (1–3), along with five known compounds, 4-vinylphenol (4) and 4-hydroxybenzaldehyde (5), 2-methoxy-2-(4'-hydroxyphenyl)ethanol (6), 2,3-dihydroxypropyl acetate (7), and phenol (8) were isolated from ethyl acetate layer of liquid fermentation with Porodaedalea pini (Hymenochaetaceae) BCRC 35384. All structures were established by spectral analysis and comparison with the literature data. Of these isolates, 1 showed moderate NO inhibitory activity with an IC 50 value of 60.0 μM . Compound 1 also showed the androgen receptor (AR) antagonism with the IC 50 value of 0.42 μM. To the best of our knowledge, this is the first report on benzenoid metabolites from the genus Porodaedalea .

Keywords: Porodaedalea pini; fungus; benzenoids; NO inhibitory activity; androgen antagonism. © 2017 ACG Publications. All rights reserved.