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A New Triterpene from Buddleja lindleyana with Neuroprotective Effect

Ya-Shuo Ren, Zheng Li, Feng-Qing Xu, Li-li Li, De-Ling Wu, Wei Zhang and Chuan-shan Jin

School of pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230012, People’s Republic of China

Anhui Innovative Team from Colleges for Scientific Research’s Platform-The Innovative Team in Researching the Key Technologies concerning the Integration of Processing Chinese Medicine Decoction Pieces in Producing Area, Hefei 230012, People’s Republic of China

Anhui Xinhua University, Hefei 230088, People’s Republic of China

Abstract: In the phytochemical investigation of Buddleja lindleyana , a new 3-acetyl substituted triterpene, 13, 28-epoxy-23-hydroxy-3β-acetoxy-olean-11-ene (1), together with four same skeleton type known compounds (2-5) were isolated. The structure of 1 was elucidated by means of extensive spectroscopic analysis. Their neuroprotective effect against 1-methyl-4 -phenylpyridinium ion-induced (MPP +-induced) neurotoxicity in SH-SY5Y cells were evaluated. The structure activity relationship of compounds 1-5 has been discussed preliminarily.

Keywords: Buddleja lindleyana ; oleanolic triterpene ; neurotoxicity effect . © 2017 ACG Publications. All rights reserved.