A New Pair of Pentaketide Diastereoisomers from Aspergillus melleus YIM PHI001
Qiang Wang, Xue-Qiong Yang, Cui-Ping Miao, Li-Hua Xu, Zhong-Tao Ding, Ya-Bin Yang and Li-Xing Zhao
Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming 650091, People’s Republic of China
Key Laboratory of Medicinal Chemistry for Natural Resource , Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091, People’s Republic of China
Abstract: Two new aspinotriol derivatives (1-2) determined as melleusin A (1), B (2) and other seven known compounds were isolated from a soil-borne fungus Aspergillus melleus. The configurations of 1, and 2 were determined by their analogues, aspilactonol B, C isolated previous in Aspergillus. Mellein (8) showed broad antibiotic activity against the test pathogens. Aspinonene, aspinotriols A and B can be used as the marker molecule in chemotaxonomy of Aspergillus.
Keywords: Aspergillus melleus; aspinotriol derivatives ; diastereoisomer; spectroscopic analyses; antibiotic. © 2018 ACG Publications. All rights reserved.