Inhibition of Various Cancer Cells Proliferation of Bornyl Acetate and Essential Oil from Inula graveolens (Linnaeus) Desf.
Tunay Karan, Ilyas Yildiz, Ali Aydin and Ramazan Erenler
Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Gaziosmanpasa University, 60240 Tokat, Türkiye
Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University, 60240 Tokat, Türkiye
Department of Biotechnology, Faculty of Science, Bartın University, 74100 Bartın, Türkiye
Abstract: Inula species are medicinal and aromatic plants used for folk medicine extensively. In this work, hydrodistilled essential oil of Inula graveolens (Linnaeus) Desf. analyzed by GC-MS which revealed that bornyl acetate was the major product (69.15%). Camphene was the second major compound (11.11%). Antiproliferative activity of the essential oil and bornyl acetate was investigated on HeLa (human cervix carcinoma), HT29 (human colon carcinoma) , A549 (human lung carcinoma), MCF7 ( human breast adenocarcinoma) cancer cells and FL (human amnion cells) normal cells. The cytotoxicity was executed by a Lactate Dehydrogenase (LDH) Cytotoxicity Detection Kit. Essential oil and bornyl acetate displayed the outstanding activities on HeLa (IC 50, 64.1, 72.0 µg/mL), HT29 (IC 50, 24.6, 60.5 µg/mL), A549 (IC 50, 28.3, 44.1 µg/mL), MCF-7 (IC 50, 66.5, 85.6 µg/mL), and FL (IC 50, 42.1, 50.6 µg/mL) cell lines respectively.
Keywords: Inula graveolens ; essential oil; antitumor activity . © 2018 ACG Publications. All rights reserved.