Records of Natural Products

Year: 2018 Volume: xx   Issue: x




The Chemical Composition and Biological Activity of the Essential Oil from the Underground Parts of Ferula  tadshikorum  (Apiaceae)

Farukh S. Sharopov, Payrav D. Khalifaev, Prabodh Satyal, Yanfang Sun, Abduahad Safomuddin, Safol Musozoda, Michael Wink and William N. Setzer

 Department of Pharmaceutical Technology, Avicenna Tajik State Medical University, Rudaki 139, 734003, Dushanbe, Tajikistan

Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany

Department of Pharmaceutical Technology and Biotechnology, National University of Tajikistan, Rudaki 17/3 , 734003, Dushanbe, Tajikistan

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA

Aromatic Plant Research Center, 615 St. George Square Court, Suite 300, Winston-Salem, NC 27103, USA

College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou 310018, China

Faculty of Chemistry, National University of Tajikistan, Rudaki 17/2 , 734003, Dushanbe, Tajikistan

 Abstract: The underground parts of Ferula  tadshikorum M. Pimenwere collected from the southern part of Tajikistan. The essential oils were obtained by hydrodistillation and analyzed by GLC-FID and GLC-MS. A total of 26 compounds were identified representing 94.4 % of total oil composition. The essential oil was dominated by the sulfur-containing compounds (Z)-1-propenyl sec-butyl disulfide (37. 3%), (E)-1-propenyl sec-butyl disulfide (29.9%), (E)-1-propenyl 1-(methylthio)propyl disulfide (16.8%), and propyl sec-butyl disulfide (4.8%). The antioxidant, antimicrobial and cytotoxic activities of the essential oil was evaluated. To our best knowledge, this is the first report concerning the chemical composition and biological activity of the essential oil obtained from the underground parts of F.  tadshikorum.

Keywords: Ferula tadshikorum ; essential oil composition; disulfides . © 2018 ACG Publications. All rights reserved.