Records of Natural Products

Year: 2018 Volume: xx   Issue: x




Biological Activities of Various Extracts from Salvia cassia Sam. ex Rech.f. and Chemical Composition of Its Most Active Extract

Burcu Sen Utsukarci, Bahar Gurda, Merve Bilgin, Dilek Satana, Betul Demirci, Nur Tan and Afife Mat

 Faculty of Pharmacy, Department of Pharmacognosy, Istanbul University, Istanbul 34116, Türkiye

Faculty of Pharmacy, Department of Pharmaceutical Botany, Istanbul University, Istanbul 34116, Türkiye

Faculty of Pharmacy, Department of Pharmaceutical Microbiology, Istanbul Yeni Yuzyil University,

Istanbul 34010, Türkiye

Faculty of Medicine, Department of Microbiology and Clinical Microbiology, Istanbul University, Istanbul 34093, Türkiye

Faculty of Pharmacy, Department of Pharmacognosy, Anadolu University, Eskisehir 26470, Türkiye

 Abstract: This study was conducted on the antibacterial, antimycobacterial and antifungal activities of various extracts (petroleum ether (PE), chloroform (CHCl 3) and ethanol (EtOH) extracts; infusion and decoction) and essential oil from the aerial parts of S. cassia Sam. ex Rech.f. and the chemical composition of the most active samples. The antibacterial activity was determined against Bacillus subtilis, Staphylococcus aureus, methicillin resistant Staphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Klebsiella pneumoniae, Proteus mirabilis and Escherichia coli. The antimycobacterial activity was analyzed against five different Mycobacterium tuberculosis and the antifungal activity was compared with two dermotophytes and three Candida species. The composition of EO was analyzed by GC-FID and GC-MS. The EO had a very good activity against B. subtilis (0.3 µL/mL) and good activity against S. aureus, methicillin resistant S. aureus (MRSA) and E. faecalis (0.6 µL/mL). All extracts were active in the antimycobacterial and antifungal tests (MICs=50-400 µg/mL). The EO was the most active samples against all Mycobacterium strains, dermatophytes and Candida species (MICs=0.1-6.25 µL/mL). Because of the high activity of EO, its composition was analyzed, and the major compound was found caryophyllene oxide (22.3%), which was also found the major components of the essential oils from other antimicrobial plants such as Salvia trichoclada Benth.

Keywords: Salvia cassia ; antimicrobial; antimycobacterial; antifungal; essential oil; caryophyllene oxide . © 2018 ACG Publications. All rights reserved.