Records of Natural Products

Year: 2018 Volume: xx   Issue: x




Wound-Healing Activity of Some Species of Euphorbia L.

 Serkan Özbilgin, Esra Küpeli Akkol, İpek Süntar, Mehmet Tekin and Gülçin Saltan İşcan

 Department of Pharmacognosy, Faculty of Pharmacy, Ankara University, 06100, Ankara, Türkiye

Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330, Ankara, Türkiye

Department of Pharmaceutical Botany, Faculty of Pharmacy, Trakya University, 22030, Edirne, Türkiye

Abstract: Some species of Euphorbia have been used as medicinal plants to treat wounds, and skin diseases, around the world. The solvents n-hexane, ethyl acetate, and methanol were used successively to prepare extracts of the aerial parts of E. characias subsp. wulfenii, E. helioscopia,E. macroclada, E. seguieriana subsp. seguieriana, and E. virgata. Linear incision, circular excision wound models and the hydroxyproline assay method were used to assess the wound-healing activity. The inhibition of the increase in capillary permeability induced by acetic acid was used to assay the anti-inflammatory activity. The methanol extract of the aerial parts of E. characias subsp. wulfenii showed statistically significant wound-healing activity with 43.03% tensile strength for the linear incision wound model and a 65.24% reduction in the area of the wound by day 10 for the circular excision model. The tissue treated with this extract was found to contain 35.47 µg/mg of hydroxyproline. The methanol extract of E. characias subsp. wulfenii inhibited inflammation induced by acetic acid with a value of 34.74%. The results showed that the aerial parts of E. characias subsp. wulfenii possess wound-healing and anti-inflammatory activities on different models.

Keywords: Euphorbia ; anti-inflammatory; excision; incision; wound-healing . © 2018 ACG Publications. All rights reserved.