Litsine A : A New A porphine A lkaloid from the Root Barks of Litsea glutinosa
Yan Jin, Younan Wu, Yiying Li, Caiyun Zhang, Wanying Sun Lin Dongand Xiaopo Zhang
Hainan Provincial Key Laboratory of R&D on Tropical Herbs , Hainan Medicinal University , Haikou 5711 99 , P.R.China
School of Pharmaceutical Sciences , Hainan Medicinal University , Haikou 5711 99 , P.R.China
School of Basic Medicine and Life Science , Hainan Medicinal University , Haikou 5711 99 , P.R.China
Abstract: A new aporphine alkaloid, named Litsine A, along with two known ones were isolated from the root barks of Litsea glutinosa . The new structure was determined by various spectroscopic techniques including 1D ( 1 H-, 13 C-NMR) , 2D-NMR (HMBC, HSQC, COSY and R OESY) and high resolution electrospray ionization mass spectrometry (HR-ESI-MS) , where as the structures of the known compounds were elucidated through 1D-NMR, mass spectrometric analysis and compared with the reported data in literature. The effects of these compounds on glucose uptake in C2C12 myotubes were evaluated at the concentration of 10μM. The three compounds exhibited potent activity , with 1 as the best one, in increasing glucose uptake.