JOURNAL


Journal of Chemical Metrology
VOLUME & ISSUE
Year: 2018 Issue: 1
PAGES
p.70 - 78
STATISTICS
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AUTHORS
    Isin Aydin Unsal, Murat Tasan, Taner Gokcen and Ahmet C. Goren
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ABSTRACT


In this study, an ID-LC-MS method was developed and validated for the determination of 14 sulfonamides in milk samples. Recovery results were found to be in the range of 91%-114% for milk samples. The relative measurement uncertainty was between 7.5%- 12.7%. Validated method was performed on milk samples obtained from market and street vendors. The amount of sulfonamides in the analyzed samples was found to be below the legal limits (Sulfamethazine: 6.46±0.76 ng/g and sulfisoxazole: 7.3±0.71 ng/g).

KEYWORDS
  • Sulfonamides
  • isotope dilution
  • LC-MS/MS
  • method validation
  • uncertainty estimation