JOURNAL 2871
Records of Natural Products
VOLUME & ISSUE
Available Online: September 14,2023
Available Online: September 14,2023
PAGES
p.1 - 5
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.413.2308.2871 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/rnp.413.2308.2871 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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GRAPHICAL ABSTRACT
ABSTRACT
One new norsesquiterpene and four known bisabolanes were obtained from the organic extract of Trichoderma atroviride TD-8 isolated from ocean sediments. Their structures were assigned by detailed interpretation of 1D/2D NMR and HRESIMS data, and they were determined to be nor-bisabolan-1,11-diol (1), (3R,6R,7R)-1,10-bisaboladien-3-ol (2), (3R,6R,7S)-1,10-bisaboladien-3,6-diol (3), (3R,6S,7R,10R)-1-bisabolen-3,10,11-triol (4), (3R,6R,7S,10R)-1-bisabolen-3,10,11-triol (5). Nor-bisabolan-1,11-diol (1) exhibited moderate cytotoxicity against HeLa and HCT-8 cell lines with IC50 values of 28.6 and 30.3 μM, respectively.
KEYWORDS- norsesquiterpene
- bisabolane
- Trichoderma atroviride
- secondary metabolites
- cytotoxic activity
