Eupatorione A, an Unusual Sesquiterpenoid from the Aerial Parts of Eupatorium adenophorum

Short Report

JOURNAL 2807

Records of Natural Products
VOLUME & ISSUE
Available Online: September 06,2023
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.23062807
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Hao Geng
  • Wen-Jie Gu
  • Jia-Hui Luo
  • Yong-Xun Yang
  • Yang Yu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Herein, the chemical analysis of petroleum ether extract of Eupatorium adenophorum was conducted which led to the identification of a previously unreported sesquiterpenoid, named eupatorione A (1). The structure of eupatorione A (1) was elucidated through comprehensive spectroscopic analysis, including 1D, 2D-NMR techniques, as well as HRMS. Additionally, X-ray diffraction was employed to further confirm the structure.  The anti-inflammatory activity of compound 1 was assessed by measuring its inhibitory effects on the production of nitric oxide (NO), induced by lipopolysaccharide (LPS) in RAW264.7 LPS-activated macrophages.

 KEYWORDS
  • Compositae
  • Eupatorium adenophorum
  • sesquiterpenoid
  • chemical structure

SUPPORTING INFORMATION

Supporting Information
Download File 411-RNP-2306-2807-SI.pdf (1.59 MB)