Organic Communications

Year: 2008 Volume: 1 Issue:4 October-December

Original Article

1) Synthesis of new dimeric carvacrol compounds

Org. Commun. (2008) 1:4 ; 69 - 75
by Uttam B. More, Hemant P. Narkhede and Pramod P. Mahulikar,

The polymer supported carvacrol anion was reacted with 1,2-dibromoethane, 1,4-dibromoethane, oxalyl dichloride, malonyl dichloride, succinyl dichloride, glutaroyl dichloride, and adipoyl dichloride to afford the corresponding dimeric carvacryl ethers or esters.

Keywords
Dimeric carvacrol ethers dimeric carvacrol esters polymer supported reactions
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© 2008 ACG Publications. All rights reserved.
Original Article

2) Copper(II) tetrafluoroborate as mild and versatile catalyst for the rapid synthesis of b -acetamido ketones and ketoesters via a three component reaction

Org. Commun. (2008) 1:4 ; 76 - 83
by Jihillu. S. Yadav, Basi. V. Subba Reddy, Kaltela S. Shankar, Kokku Premalatha,

A variety of β-acetamido ketones and ketoesters are readily prepared in high yields under extremely mild conditions via a three component coupling of aromatic aldehydes, enolizable ketones or β-ketoesters and nitriles in the presence of 10 mol% of copper(II) tetrafluoroborate and a stoichiometric amount of acetyl chloride. A solution of 10 mol% of Cu(BF 4) 2 in acetonitrile provides a convenient reaction medium to carry out a three component reaction under mild conditions

Keywords
β-Acetamido carbonyl compounds aromatic aldehydes enolizable ketones copper(II) tetrafluoroborate
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© 2008 ACG Publications. All rights reserved.
Original Article

3) Synthesis and biological study of novel methylene-bis-benzofuranyl-[1,5]-benzothiazepines

Org. Commun. (2008) 1:4 ; 84 - 94
by Sanjeeva R. Cherkupally, Purnachandra R. Gurrala, Nagaraj Adki, Srinivas Avula

A series of novel methylene-bis-[1,5]-benzothiazepines 4 andmethylene-bis-benzofuranyl-[1,5]-benzothiazepines 5 were prepared by the reaction of methylene-bis-chalcones 3 with 2-aminothiophenol followed by the condensation with α-bromoacetophenone. The structures of the synthesized compounds were confirmed by their IR, 1H, 13C NMR and Mass spectral analyses. All the synthesized compounds were tested for their antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. Among the synthesized compounds, the compounds 4f, 4g, 5f and 5g were found to be the most active against Bacillus subtilisBacillus sphaericusStaphylococcus aureusKlebsiella aerogenes and Chromobacterium violaceum. Similarly these compounds showed potent antifungal effect against Candida albicansAspergillus fumigatusTrichophyton rubrum, and Trichophyton mentagrophytes. It is interesting to note that the compounds with heterocyclic ring substituents at the 4th position of benzothiazepine system displayed notable antibacterial activity, almost equal to that of streptomycin and penicillin.

Keywords
Methylene-bis-[1 5]-benzothiazepines Methylene-bis-benzofuranyl-[1 5]-benzothiazepines Antibacterial activity Antifungal activity.
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© 2008 ACG Publications. All rights reserved.