4.

An improved process for eszopiclone: Anti-insomnia agent

Kandala S. Charyulu, Chinta R. Reddy, Kisara Satyanarayana, Mandava V. N. B. Rao, V.V.N.K. Prasad Raju, Adla V. Kumar, Virumudi H. Bindu, Vijayavitthal T. Mathod, Apurba Bhattacharyaand Rakeshwar Bandichhor,

Org. Commun. (2008), 1:2; 33-38

Research & Development, Integrated Product Development, Dr. Reddy’s Laboratories Ltd., Survey Nos. 42,45,46, & 54 Bachupally, Qutubullapur, Ranga Reddy Dist 500072, Andhra Pradesh, India. Institute of Science and Technology, Center for Environmental Science, J.N.T. University , Kukatpally, Hyderabad- 500 072, A .P, India . IPDO communication number: IPDO-IPM00106

Abstract: Application of stable hydrochloride salt of 1-chlorocarbonyl-4-methylpiperzine 2 and tetrabutyl ammonium bromide (TBAB) as a phase transfer catalyst in an improved process of eszopiclone 1 is presented.

Key words: Zopiclone; phase transfer catalyst; resolution.