Glycerin as alternative solvent for the synthesis of Thiazoles
A. Venkat Narsaiah, Ramesh S. Ghogare and Dhanraj O. Biradar
Organic Chemistry Division, Indian Institute of Chemical Technology, Hyderabad, 500007, India .
Abstract: A variety of α-bromoketones undergoes smooth condensation with thiourea/ thioamide compounds to afford the corresponding substituted thiazole derivatives in excellent yields. The condensation reactions were carried out in a recyclable reaction medium glycerin without using any catalyst. All the reactions were completed within 2 hours of reaction time at room temperature.
Keywords: Bromo ketone; thiourea; urea; thiazole; catalyst-free; glycerin. |