Synthesis and evaluation of a series of pyrimidine substituted 1,3,4-oxadiazole derivatives as antimicrobial and anti-inflammatory agents
Sanath Kumar Goud Palusa, Rajgopal H.Udupi, Himabindu. and Ajjanna M Sridhara
Department of Chemistry, Jawaharlal Nehru Technological University Kukatpally, Hyderabad -500072. INDIA
Department of Pharmaceutical Chemistry, NET Pharmacy College, Raichur- 584103. INDIA
Department of Industrial Chemistry, Kuvempu University, Shimoga-577 451. INDIA
Abstract: Novel pyrimidine substituted 1,3,4-oxadiazole derivatives (11a-k) were synthesized from the condensation of different substituted aromatic carboxylic acids with substituted pyrimidine carboxy hydrazide using POCl3 as condensing agent. Their structures were characterized by physical and spectral studies. The synthesized compounds were evaluated for their in vitro antimicrobial and anti-inflammatory activity. Some of the newly synthesized compounds showed good antimicrobial and anti-inflammatory activities.
Keywords: 1,3,4-oxadiazole; pyrimidine; antibacterial; antifungal; anti-inflammatory. |