2.

Synthesis, spectral characterization and anti-microbial activity of 6- Substituted [(2-aminoethyl)amino]-6λ 5-dibenzo [d, h] [1, 3,6,2]oxathiaza- phosphonin-6-ones

Chinta Raveendra Reddy, Katla Venkata Ramana, Chinthaparthi Radha Rani, Gangireddy Chandra Sekhar Reddy, Vallasani Koteswara Rao and

Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India.

Department of Polymer Science and Engineering, Pusan National University, Pusan 609-735, Republic of Korea.

Abstract: Synthesis of a series of a new class of phosphorus macrocycles was accomplished in two steps by condensation of (Z)-2-((2-mercaptophenylimino) methyl) phenol (1) with phosphorus oxychloride (2) in dry THF in the presence of triethylamine at 0-5 °C. In the second step ethylene diols/ amino alcohols/ diamine/ aminothiols/ phenols were reacted at room temperature in THF to afford the title compounds (5a-l). The chemical structures of the title products were characterized by IR, 1H, 13C, 31P-NMR, mass spectral studies and elemental analysis. All the title compounds were evaluated for antimicrobial activity to determine their efficacy and they were found role effective in suppressing the growth of bacteria and fungi.

Keywords: Phosphorus macrocycles; antimicrobial activity; anti-bacterial activity; anti-fungal activity.