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Synthesis and characterization of new analogs of zafirlukast

Gilla Goverdhan, Anumula Raghupathi Reddy, N. Rama Krishna Reddy, Kurella Srinivas, Vurimidi Himabindu and Ghanta Mahesh Reddy

Research and Development, Dr. Reddy’s Laboratories Ltd, Integrated Product Development, Survey No’s 42, 45, 46 & 54, Bachupally, Qutubullapur, Ranga Reddy District-500 072, Andhra Pradesh, India

Institute of Science and Technology, Center for Environmental Science, J.N.T. University, Kukatpally, Hyderabad-500 072, Andhra Pradesh, India

Research and Development, Macleods Pharmaceuticals, Andheri East, Mumbai-400059, Maharashtra, India

Abstract: Design, synthesis and characterization of four novel series of Zafirlukast analogs are described. The modifications are substitution on indole nitrogen, C-5 position of indole moiety and amide nitrogen of zafirlukast.

Keywords:Zafirlukast; anti asthma; new analogs; N-desmethyl zafirlukast analogs; DCU analogs.