10.

An efficient conversion of maleimide derivatives to 2-thioxo imidazolidinones.

Lydia Salhi, Samia Bouzroura-Aichouche, Yamina Benmalek, Yamina Bentarzi, Sophie Poulain-Martini, Bastien Cacciuttolo, Elisabet Dunach and Bellara Nedjar-Kolli

Laboratory of Applied Organic Chemistry, Houari Boumediene University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar, 16111, Algiers, Algeria

Laboratory of microbiology, Houari Boumediene, University of Sciences and Technology, BP 31, El-Alia, Bab-Ezzouar 16111, Algiers, Algeria

Institut de Chimie de Nice UMR 7272, Université de Nice-Sophia Antipolis, CNRS, Parc Valrose, 06108 Nice Cedex 2, France

Abstract: Starting from maleimide derivatives, a series of 2-thioxoimidazolidinones was prepared through two different procedures. These syntheses have achieved in two steps via reaction between maleimide derivatives 1,semicarbazide hydrochloride 9 and isothiocyanates5,the best results being obtained under acid conditions (AcOH or heteropolyacid in ethanol or acétonitrile). The synthesized compounds 11a-f and substituted thiohydantoins 6a-h, 8a-h were screened for their in vitro anti-bacterial activity against four bacterial strains.

Keywords: Maleimide, Thiohydantoin, antibacterial activity.