Bleaching earth clay (pH 12.5): A novel and reusable catalyst for rapid synthesis of 7-Hydroxy 4-Styryl coumarin derivatives and their antihelmintic activity
Rahul D. Kamble, Govind V. Jawadwar, Snehalkumar D. Patil, Shrikant V. Hese, Ashok P. Acharya, Bhaskar S. Dawane and Sanjay S. Pekamwar
School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded (MS) India. 431606.
School of Pharmacuetucal Sciences, Swami Ramanand Teerth Marathwada University, Nanded (MS) India. 431606
Abstract: 7-hydroxy 4-styryl coumarin derivatives were synthesized by Knovengel condensation of 7-hydroxy 4-methyl coumarin with aldehydes by using novel and reusable catalyst bleaching earth clay (pH12.5) in PEG-400 as green reaction solvent, followed by the Mannich reaction. The synthesized compounds were evaluated for their in vitro antihelmintic activity and it was found that the synthesized compounds showed good antihelmintic activity.
Keywords: 7-hydroxy 4-styryl coumarin derivatives; bleaching earth clay (pH12.5); PEG-400; antihelmintic activity; albendazole. |