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Synthesis and in vitro cytotoxic effect of some novel 4H-furo [3,2–c]pyran-4-one derivatives

İrfan Koca, Halil Erhan Eroğlu and Ertan Şahin

Department of Chemistry, , Bozok University, 66200 Yozgat, Türkiye

Department of Biology, Bozok University, 66200 Yozgat, Türkiye

Department of Chemistry, Atatürk University, 25240 Erzurum, Türkiye

Abstract: We report a series of novel 4H-furo[3,2–c]pyran-4-one derivatives. Structures of synthesized compounds were determined by the IR, NMR, elemental analysis and X-ray diffraction method. All the compounds were tested for genotoxicity in human lymphocytes cultures. Sister chromatid exchange (SCE), micronucleus (MN), mitotic index (MI) and replication index (RI) tests are used in toxicological screening for potential cytotoxic and genotoxic effects. According to the results of the genotoxic tests, the 4H-furo[3,2–c]pyran-4-one derivatives induce the frequencies of these parameters. The results showed that these compounds are potential genotoxic and cytotoxic compounds at high concentrations (especially 1 and 2 mg/mL).

Keywords: 2,3-furandione; pyran-2-one; 4H-furo[3,2–c]pyran-4-one; cyctoxic activity. © 2014 ACG Publications. All rights reserved.