2.

Some new azole type heterocyclic compounds as antifungal agents

Mohammad Russell, and Mohammad Ikthair Hossain Soiket

Department of Textile Engineering, Bangladesh University of Business and Technology, Mirpur-2, Dhaka-1216, Bangladesh

Department of Mechanical Engineering, Bangladesh University of Engineering and Technology, Polashi, Dhaka-1000, Bangladesh

Abstract: Schiff’s base1-[(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)]ethanone thiosemicarbazone (compound 1A) wasprepared by condensation of 1-(2,4-difluorophenyl)-2- [1 (H)-1,2,4-triazol-1-yl]ethanone (1)with thiosemicarbazide. The compound 1A, on reaction with α-halogenoketones yielded 1-(2, 4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1-yl] ethanone [2-[4-halogenophenyl] thiazolyl]hydrazone.Anti-fungal activity of all the compounds has been tested against four fungal organism: C. albicans , Colletotrichum spp., A. nigar and Fusarium spp. commonly responsible for fungal infections in Bangladesh.

Keywords: Schiff’s bases; compound 1A; 1-(2,4-difluorophenyl)-2- [1 (H)-1,2,4-triazol-1-yl] ethanone (1); α-halogenoketones; 1-(2,4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1-yl] ethanone [2-[4-halogenophenyl] thiazolyl] hydrazone;Anti-fungal activity.© 2014 ACG Publications. All rights reserved.