Synthesis and antibacterial activity of 2-amino chromenes arising cyanoiminocoumarins and β-naphthol

Lamia Dammak, Mariem Kammoun, Noureddine Allouche, Houcine Ammar and Souhir Abid

Laboratoire de Chimie Appliquée: Hétérocycles, Corps Gras et Polymères, Faculté des Sciences de Sfax, Université de Sfax, Route Soukra, BP1171, 3000 Sfax, Tunisie

Laboratoire de Chimie des Substances Naturelles (UR11/ES74), Faculté des Sciences de Sfax, Université de Sfax, Route Soukra, BP1171, 3000 Sfax, Tunisie

Abstract: The synthesis of 2-amino chromene, reported in our previous paper, has been accomplished by the reaction of cyanoiminocoumarin and β-naphthol . The obtained compound was reacted   with various electrophilic or nucleophilic reagents. All the new homologous 2-amino-4H-chromenes have been characterized on the basis of their spectral (IR, 1H and 13C NMR) data and microanalysis. Four compounds were evaluated   in vitro  for their preliminary antibacterial activities against five different pathogenic bacterial strains such as Bacillus thuringiensis , Escherichia coli , Staphylococcus aureus, klebsiella pneumonia and Salmonella Sp . Antibacterial activity of each compound was compared with standard drug, Penicillin .

Keywords: Cyanoiminocoumarins; 2-amino-4H-chromene; β-naphtol; antibacterial activity .© 2017 ACG Publications. All rights reserved.