6.

Chemical Composition and Antimicrobial Activity of the Essential Oils of Ageratum fastigiatum (Asteraceae)

Glauciemar Del-Vechio-Vieira, Orlando V. Sousa, Célia H. Yamamoto and Maria A.C. Kaplan

Museu Nacional, Universidade Federal do Rio de Janeiro, Quinta da Boa Vista, São Cristóvão, 20940-040, Rio de Janeiro, Rio de Janeiro, Brasil

Departamento Farmacêutico, Faculdade de Farmácia e Bioqumica, Campus Universitário, Martelos, 36036-330, Juiz de Fora, Minas Gerais, Brasil

Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro,Centro de Ciências da Saúde, Rio de Janeiro, Cidade Universitária, 21941-590, Rio de Janeiro, Rio de Janeiro, Brasil

Abstract: Essential oils from different organs of Ageratum fastigiatum (Gardn.) R. M. King et H. Rob., obtained by hydrodistillation were analyzed through Gas Chromatography and Gas Chromatography/Mass Spectrometry. The essential oils were tested for antimicrobial activity by the agar-diffusion method and minimal inhibitory concentration (MIC). The main compounds found were b -caryophyllene, germacrene D and 1,10-di-epi-cubenol. The samples were active against Staphylococcus aureus, Streptococcus mutans, Streptococcus faecalis, Salmonella typhosa, Escherichia coli, but not Pseudomonas aeruginosa and fungi. The MIC ranged from 5.0 to 18.0 mg/mL.

Keywords: Ageratum fastigiatum ; essential oil composition; β-caryophyllene; germacrene-D; 1,10-di-epi-cubenol; antimicrobial activity