10.

Phytochemical Studies on Polygonum barbatum (L.) Hara var. barbata (Polygonaceae)

M. Abdul Mazid, Bidyut K. Datta, Lutfun Nahar, S. A. M. Khairul Bashar, Sitesh C. Bachar and Satyajit D. Sarker

Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh

Department of Pharmaceutical Technology, University of Dhaka, Dhaka 1000, Bangladesh

Drug Discovery and Design Research Division, Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, City Campus South, MA Building, Wulfruna Street, Wolverhampton WV1 1LY, England, UK

North South University, 12, Kemal Attaturk Avenue in Banani, Dhaka, Bangladesh

Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, MM Building, Molineux Street, Wolverhampton WV1 1SB, England, UK

Abstract: Polygonum barbatum (L.) Hara var. barbata (Polygonaceae), commonly known as ‘bekhanjabaj’, is a Bangladeshi perennial herb. A combination of the normal phase column chromatography and preparative thin layer chromatography on silica gel afforded sitosterone (1) from the petroleum ether fraction, and viscozulenic acid (2) and acetophenone (3) from the chloroform fraction of the methanol extract of the aerial parts of this plant . The free-radical-scavenging properties the isolated compounds 1-3 were evaluated by the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) assay.

Keywords: Polygonum barbatum (L.) Hara var. barbata ; Polygonaceae; acetophenone; viscozulenic acid; sitosterone; sesquiterpene; DPPH .