1.

Kitasatodine and Kitasatopenoid fromKitasatospora sp. H6549, a New Strain from Malaysia

Niuniu Shi, Chunhua Lu, Coy Choke Ho and Yuemao Shen

Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering; School of Life Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. China,

School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250100, P. R. China, 3Research Office, 4 -12A, Fortuna Court, 54, Jalan Awan Cina, Taman Yarl, 58200 Kuala Lumpur, Malaysia

Abstract: A new pyridine-containing natural product, kitasatodine (1), and a new sesquiterpene, kitasatopenoid (2), together with a known cycloheximide (3) were isolated from the ethyl acetate extract of the strain H6549 (Kitasatospora sp.), which was isolated from dipterocarp forest of Kepong Kuala Lumpur in Malaysia. Their structures were established by spectroscopic methods including 1D and 2D-NMR experiments and HR-Q-TOF-MS. In addition, compounds 1 and 2 showed moderate cytotoxicity against HeLa and HepG-2 cell lines.

Keywords: Kitasatospora sp.;kitasatodine; kitasatopenoid; spectroscopic; cytotoxicity .