Untitled Document

Records of Natural Products

Year: 2014 Volume: 8 Issue: 3

ORIGINAL ARTICLE

Chemical Diversity and Biological Activity of the Volatiles of Five Artemisia Species from Far East Russia

Gulmira Özek, Yerlan Suleimen, Nurhayat Tabanca, Roman Doudkin, Petr G. Gorovoy, Fatih Göger, David E. Wedge, Abbas Ali, Ikhlas A. Khan and Kemal Hüsnü C. Başer

Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskişehir, 26470, T ürkiye

The Institute of Applied Chemistry, Department of Chemistry, L.N. Gumilyov Eurasian National Universi ty, 010 008 Astana, Kazakhstan

National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA,

Labora tory of Chemota xonomy, Pacific Institute of Bioorganic Chemistry of the Far Eastern Branch of the Russian Academy of Sciences, 690 022 Vl adivostok, Russia

Department of Biodiversity and Marine Biology, School of Natural Sciences, Far Eastern Federal University, 8, Sukhanovast ., 69 0950, Vl adi vostok, Russia

Laboratory of Flower Introduction, Botanical Garden Institute of the Far Eastern Branch of the Russian Academy of Sciences, 142, Makovskogo., 69 0024, Vladivostok, Russia

USDA-ARS Natu ral Produc ts Utilization Research Unit, University of Mississippi, University, MS 38677 USA

Department of Pharma cognosy, S chool of P har macy, The Univ ersi ty of M ississippi, University, M S 38677 USA

Department of Botany and Microbiology, King Saud University, College of Science, 11451 Riyadh, Saudi Arabia

Bahcesehir University, Technology Transfer Office, Besiktas, 34353 Istanbul, Türkiye

Abstract: Artemisia argyi, A. feddei, A. gmelinii, A. manshurica, and A. olgensis (Asteraceae) were collected in Far East Russia. Oils were hydrodistilled and simultaneously analyzed by GC-FID and GC/MS. Main constituents were found as follows in Artemisia oils: selin-11-en-4 a -ol (18.0%), 1,8-cineole (14.2.0%), artemisia alcohol (12.9%), borneol (9.7%) in A. argyi; camphor (31.2%), 1,8-cineole (17.6%), a -thujone (5.7%) in A. feddei; longiverbenone (12.0%), isopinocamphone (8.9%), 1,8-cineole (6.7%), camphor (5.8%), trans-p-menth-2-en-1-ol (5.3%) in A. gmelinii; germacrene D (11.2%), rosifoliol (10.1%), caryophyllene oxide (6.8%), eudesma-4(15),7-dien-1 b -ol (5.6%) in A. manshurica; eudesma-4(15),7-dien-1 b -ol (6.9%), caryophyllene oxide (5.6%), guaia-6,10(14)-dien-4 b -ol (5.1%) and hexadecanoic acid (5.0%) in A. olgensis. Oils were subsequently submitted for antifungal and antimosquito evaluations. Artemisia species oils showed biting deterrent effects in Aedes aegypti and Artemisia gmelinii oil with the most active biting deterrence index values of 0.82 ± 0.1 at 10 m g/mL. Larval bioassay of A. gmelinii and A. olgensis oils showed higher larvicidal activity against Ae. aegypti larvae with LD50 values of 83.8 (72.6 – 95.7) ppm and 91.0 (73.8 – 114.5) ppm, respectively. Antifungal activity was evaluated against the strawberry anthracnose-causing fungal plant pathogens Colletotrichum acutatum, C. fragariae and C. gloeosporioides using direct overlay bioautography assay and all showed non-selective weak antifungal activity. Antioxidant evaluations of the oils were performed by using b -carotene bleaching, Trolox equivalent and DPPH tests. The tested Artemisia oils demonstrated moderate antioxidant activity.